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Magnesium has the potential to be used as degradable metallic biomaterial. For magnesium and its alloys to be used as biodegradable implant materials, their degradation rates should be consistent with the rate of healing of the affected tissue, and the release of the degradation products should be within the body's acceptable absorption levels. Conventional magnesium degrades rapidly, which is undesirable...
This study aimed to create hydroxyapatite (HAp) film by powder jet deposition with manipulating the blasting nozzle above human enamel and to examine the microstructural and mechanical properties of the HAp film and the bonding strength at the interface between the HAp film and the enamel substrate. HAp particles calcinated at 1200°C with an average size of 4.7 μm were used. The HAp particles were...
Our purpose of this study is to develop potassium or sodium/strontium co‐substituted calcium polyphosphate (K/Sr‐CPP or Na/Sr‐CPP) bioceramics in application of bone repairing scaffold. The incorporation of K, Na, and Sr into CPP substrate via a calcining‐sintering process was confirmed by X‐ray diffractometry and inductively coupled plasma atomic emission spectroscopy. In vitro degradation study...
Gellan gum is an attractive biomaterial for fibrocartilage tissue engineering applications because it is cell compatible, can be injected into a defect, and gels at body temperature. However, the gelling parameters of gellan gum have not yet been fully optimized. The aim of this study was to investigate the mechanics, degradation, gelling temperature, and viscosity of low acyl and low/high acyl gellan...
Degradable polymer‐based materials are attractive in orthopedics and dentistry as an alternative to metallic implants for use as bone fixatives. Herein, a degradable polymer poly(lactic acid) (PLA) was combined with novel hybrid nanopowder of carbon nanotubes (CNTs)‐calcium phosphate (CP) for this application. In particular, CNTs‐CP hybrid nanopowders (0.1 and 0.25% CNTs) were prepared from the solution...
Desirably porous biodegradable hybrid composite microspheres were fabricated for use in bone graft and bone substitute applications. In this study, novel poly(ε‐caprolactone)/biphasic calcium phosphate (70/30) composite microspheres (PCL/BCP MPs) were prepared using the emulsion solvent‐evaporation method. Throughout this process, the ammonium bicarbonate (NH4HCO3) content was changed to obtain the...
Treatment of wounds using negative pressure wound therapy (NPWT) uses a nondegradable polyvinyl alcohol (PVA) foam in the application of negative pressures typically for 1–3 days. The purpose of this study was to construct and test biodegradable poly(ε‐caprolactone) (PCL) foam as a substitute for the PVA foam. Such a foam would be left within the wound until healing was achieved and form a biodegradable...
Hard coatings for articulating surfaces of total joint replacements may improve the overall wear resistance. However, any coating approach must take account of changes in corrosion behavior. This preliminary assessment analyzes the corrosion kinetics, impedance and mechanical–electrochemical stability of 100 μm thick plasma sprayed chromium oxide (Cr2O3) coatings on bearing surfaces in comparison...
Articular cartilage has a poor healing capacity, and cartilage regeneration is not always warranted to achieve healing. On the other hand, collagen scaffolds have been shown to support regeneration of articular cartilage defects in animal models, whereas bone morphogenetic protein‐2 (BMP‐2) is known to cause chondrogenic differentiation of marrow‐derived mesenchymal stem cells (MSCs). The purpose...
Composite films of bioactive mesoporous calcium silicate (MCS)/silk fibroin (SF) and conventional calcium silicate (CS)/SF were fabricated by the solvent casting method, and the structures and properties of the composite films were characterized. Results of field emission scanning electron microscope (FESEM) indicated that MCS or CS was uniformly dispersed in the SF films. The measurements of the...
The purpose of this study was to evaluate and compare plasma pharmacokinetics, lung tissue concentration, and the potential toxicity of drug eluting beads loaded with irinotecan (DEB‐IRI) in a sheep pulmonary artery chemoembolization (PACE) model. Sheep (n = 24) were embolized with DEB‐IRI loaded with different doses (0, 20, 50, or 100 mg). Direct pulmonary artery (PA) injections of irinotecan were...
Implantable devices realized by microfabrication have introduced a new class of potential biomaterials whose properties would need to be assessed. Such devices include sensors for measuring biological substances like glucose. Thus, 14 different candidate materials intended for design of such a device were investigated with respect to their complement activation potential in human serum. The fluid‐phase...
Triethyleneglycol dimethacrylate (TEGDMA) and 2‐hydroxyethyl methacrylate (HEMA) are major resinous components of dental restorative materials and dentin bonding adhesives. Resin monomers are known to cause cytotoxicity in mammalian cells via oxidative stress and inhibit differentiation of dental pulp cells and osteoblasts. This study was aimed to investigate whether oxidative stress was involved...
Structurally well‐defined trimethylated chitosan‐O‐poly(ε‐caprolactone) (TMC‐O‐PCL) was synthesized under mild homogeneous conditions, using sodium dodecyl sulfate‐dimethylated chitosan complex (SDC) as an organosoluble intermediate. The effect of chitosan molecular weight (MW) on the preparation, organosolubility, self‐assembly, and cytotoxicity of the copolymers was investigated. The copolymers...
Hydroxyapatite was coated on the Ti implants by a new coating method called low temperature high speed collision (LTHSC). Higher roughness values were estimated in the formed thick coating on the implant surface. While the roughness value was lower than plasma sprayed HA coatings, LTHSC HA‐coated surface showed higher hydrophilicity. The cell proliferation of oseteoblastic cells evaluated by MTT assay...
The need for a suitable scaffolding material for load bearing bone tissue engineering still has yet to be met satisfactorily. In this study, Portland cement and Portland cement/metakaolin (MK) blends were processed to render them biologically and mechanically suitable for such application. Portland cement was mixed with MK at different ratios. The slurries were hydrated under atmospheric (noncarbonated...
Commercially available drug‐eluting stents have the potential to induce inflammatory and hypersensitive adverse reactions due to their polymer coating. The use of self assembled monolayers (SAMs) as an alternate drug delivery platform for stents has recently been demonstrated. In this study, the formation and stability of phosphonic acid SAMs were investigated using the material and surface preparation...
In this study, the effect of feed composition, degree of hydrophilicity, and internal morphology has been investigated for cell proliferation potential of the polyacrylamide/gelatin (PAm/G) semi‐interpenetrating polymeric network (semi‐IPNs). Polycaprolactone diacrylate was used to cross‐link polyacrylamide chains. Scanning electron microscopy (SEM) micrographs demonstrate uniformly distributed porous...
A facile and efficient single‐step mineralization approach was exploited for achieving nanoscopic hydroxyapatite (HAP) crystal layer in chitosan porous matrix, wherein a mixed water–ethanol solvent was used to control the growth of minerals. The crystallographic structure, morphology, and mechanical properties of the scaffold were analyzed with XRD, FTIR, environmental scanning electric microscopy...
Previously, nano‐sized calcium fluoride (CaF2) particles were prepared using a spray drying method by simultaneously feeding Ca(OH)2 and NH4F solutions to a two‐liquid nozzle. The aim of the present study was to prepare better‐dispersed nano‐CaF2 particles by co‐forming a soluble salt, sodium chloride (NaCl). NaCl of various concentrations were added to the NH4F solution, leading to formation of (CaF...
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